Literature References

1. Moyer MP, Stauffer JS, Manzano LA, Tanzer LR, Merriman RL. NCM460, A Normal Human Colon Mucosal Epithelial Cell Line. In Vitro Cell Dev Biol: Animal 32:315-317, 1996.
   

2. Kumar CK, Moyer MP, Dudeja PK, Said HM. A Protein Tyrosine Kinase Regulated, pH-Dependent Carrier-Mediated Uptake System for Folate by Human Normal Colonic Epithelial Cell Line NCM460. J. Biol. Chem, 272:6226-6231, 1997.
   

3. Ferris HA, Carroll RE, Rasenick MM, Benya RV. Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460. J Clin Invest 100(10):2530-7, 1997.
   

4. Ferris HA, Carroll RE, Lorimer DL, Benya RV. Location and characterization of the human GRP receptor expressed by gastrointestinal epithelial cells. Peptides 18(5):663-72, 1997.
   

5. Sahi J, Nataraja SG, Layden TJ, Goldstein JL, Moyer MP, Rao MC. Cl-Transport in an Immortalized Human Epithelial Cell Line (NCM460) Derived from the Normal Transverse Colon. Am. J. Physiol. 275:C1048-C1057, 1998.
   

6. Him EC, Zhu Y, Andersen V, Sciaky D, Cao HJ, Meekins H, Smith TJ, Lance P. Cytokine-mediated PGE2 expression in human colonic fibroblasts. Amer J Physiol 275(4 Pt 1):C988-94, 1998.
   

7. Said HM, Ortiz A, McCloud E, Dyer D, Moyer MP, Rubin S. Biotin Uptake by Human Colonic Epithelial NCM460 Cells: A Carrier-Mediated Process Shared with Pantothenic Acid. Am J Physiol 275(5 Pt 1):C1365-71, 1998.
   

8. Backert G, Gelos M, Kobalz U, Hanski ML, Bohm C, Mann B, Lovin N, Gratachev A, Mansmann U, Moyer MP, Riecken EO, Hanski C. Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array. Intl J Cancer 82:868-74, 1999.
   

9. Rah SY, Izbicka E, Lawrence R, Davidson D, Sun D, Moyer MP, Roodman D, Hurley L, Von Hoff D. Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin Cancer Res 6:987-993, 2000.
   

10. McMasters RA, Wilbert TM, Jones KE, Pitlyk K, Saylors RL, Moyer MP, Chambers TC, Drake RR. Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. Cancer Gene Therapy 7:563-573, 2000.
    

11. Sundaram U. Regulation of intestinal vitamin B(2) absorption. Focus on “Riboflavin uptake by human-derived colonic epithelial NCM460 cells”. Amer J Physiol-Cell Physiol 278(2):C268-9, 2000.
    

12. Drake RR, Pitlyk K, McMasters RA, Mercer KE, Young H, Moyer MP. Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing cell line. Mol. Ther. 2:515-523, 2000
    

13. Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffman I, Mueller O. Seven genes that are differentially transcribed in colorectal tumor cell lines. Cancer Lett. 160:37-43, 2000.
    

14. Said HM, Ortiz A, Moyer MP, Yanagawa N. Riboflavin uptake by human-derived colonic epithelial NCM460 cells. Am J Physiol Cell Physiol 278:C270-276, 2000.
    

15. Zhao D, Keates AC, Kuhnt-Moore S, Moyer MP, Kelly CP, Pothoulakis C. Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes. J Biol Chem. 276(48):44464-71, 2001.
    

16. Said HM, Ortiz A, Subramanian VS, Neufeld EJ, Moyer MP, Dudeja PK. Mechanism of thiamine uptake by human colonocytes: studies with cultured colonic epithelial cell line NCM460. Am J Physiol Gastrointest Liver Physiol. 281(1):G144-50, 2001.
    

17. Zhao D, Kuhnt-Moore S, Zeng H, Pan A, Wu JS, Simeonidis S, Moyer MP, Pothoulakis C. Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Biochem J. 368:665-72, 2002.
    

18. Elmore E, Siddiqui S, Desai N, Moyer MP, Steele VE, Redpath JL. The human epithelial cell cytotoxicity assay for determining tissue specific toxicity: method modifications. Methods Cell Sci. 24:145-53, 2002.
    

19. Zhao D, Kuhnt-Moore S, Zeng H, Wu JS, Moyer MP, Pothoulakis C. Neurotensin stimulates interleukin-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-B pathways. Am J Physiol-Cell Physiol 284:C1397-404, 2003.
    

20. Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson B. Anthocyanin-rich extract from Aronia Meloncarpa E induced cell cycle block in colon cancer but not normal colonic cells. Nutrit. Cancer, 46:186-196, 2003.
    

21. Rhee SH, Keates AC, Moyer MP, Pothoulakis C. MEK is a key modulator for TLR5-induced interleukin-8 and MIP3 alpha gene expression in nont-transformed human colonic epithelial cells. J Biol Chem. 11;279(24):25179-88, 2004.
    

22. Huang XW, Lieber A, Tang ZY, Lawrence TS, Moyer MP, Zhang M. Gene expression in intrahepatic tumors through DNA recombination by a replication-activated adenovirus vector. Cancer Gene Ther. 11(6):450-456, 2004.
    

23. Zhao D, Zhan Y, Koon HW, Zeng H, Keates S, Moyer MP, Pothoulakis C. Metalloproteinase-dependent transforming growth factor-alpha release mediates Neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem. 279(42):43547-54, 2004.
    

24. Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C. Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem. 279(44):45519-27, 2004.
    

25. Zhao C, Giusti MM, Malik M, Moyer MP, Magnuson BA. Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J Agric Food Chem 52(20):6122-8, 2004.
    

26. Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, Lamont JT. Clostridium difficile toxin A regulates inducible COX-2 and PGE2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem 28(22):21237-45, 2005.
    

27. Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C. Neurotensin stimulates interleukin-8 expression through modulation of I (kappa) B (alpha) phosphorylation and p65 transcriptional activity: involvement of protein kinase c (alpha). Mol Pharmacol. 67(6):2025-31, 2005.
    

28. Na X, Zhao D, Koon HW, Kim H, Husmark J, Moyer MP, Pothoulakis C, LaMont JT. Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Gastroenterology 128(4):1002-11, 2005.
    

29. Koon HW, Zhao D, Zhan Y, Simeonidis S, Moyer MP, Pothoulakis C. Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase C delta activation. J Pharmacol Exp Ther 314(3):1393-400, 2005.
    

30. Kim H, Kokkotou E, Na X, Rhee SH, Moyer MP, Pothoulakis C, Lamont JT. Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology 129(6):1875-88, 2005.
    

31. Rhee SH, Kim H, Moyer MP, Pothoulakis C. Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem. 281(27):18560-8, 2006.
    

32. Koon HW, Zhao D, Zhan Y, Rhee SH, Moyer MP, Pothoulakis C. Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells. J. Immunol. 176(8):5050-9, 2006.
    

33. Chen X, Kokkotou EG, Mustafa N, Bhaskar KR, Sougioultzis S, O’Brien M, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 281(34):24449-54, 2006.
    

34. Zhao D, Zhan Y, Zeng H, Moyer MP, Mantzoros CS, Pothoulakis C. Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. J Cell Bioch. 97:1317-27, 2006.
    

35. Chiu TT, Leung WY, Moyer MP, Strieter RM, Rozengurt E. Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. Am J Physiol Cell Physiol. 292(2):C767-77, 2007.
    

36. Planoutis K, Plonoutene M, Moyer MP, Milovanovic T, Holcombe RF. Regulation of norrin receptor frizzled-4 by Wnt2 in colon derived cells. BMC Cell Biol 8(1):12, 2007.
    

37. Koon HW, Zhao D, Zhan Y, Moyer MP, Pothoulakis C. Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proc Natl Acad Sci USA 104(6):2013-8, 2007.
    

38. Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C. Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer 120(8): 1652-6, 2007.
    

39. Minoo P, Moyer MP, Jass JR. Role of BRAF-V600E in the serrated pathway of colorectal tumorigenesis. J Pathol. 212(2): 124-33, 2007.
    

40. Crott JW, Liu Z, Keyes MK, Choi SW, Jang H, Moyer MP, Mason JB. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. J Nutr Biochem. Aug 1, 2007.

41. Lea MA, Ibeh C, Shah N, Moyer MP. Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase. Anticancer Res. 2007 Mar-Apr;27(2):741-8, 2007.

42. Moss AC, Anton P, Savidge T, Newman P, Cheifetz AS, Gay J, Paraschos S, Winter MW, Moyer MP, Karalis K, Kokkotou E, Pothoulakis C. Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut Sep;56(9):1210-7, 2007. Epub 2007 Apr 5.
    

43. DeAngelo AB, Jones CP, Moyer MP. Development of normal human colon cell cultures to identify priority unregulated disinfection by-products with a carcinogenic potential. Water Sci Technol. 56(12):51-5, 2007.
    

44. Engelbrecht AM, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K. Proanthocyanid from grape seeds inactivates the P13-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett 258(1):144-53, 2007.
    

45. Kim H, Rhee SH, Pothoulakis C, Lamont JT. Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand. Gastroenterology. 133(3):875-886, 2007.
    

46. Brothakur A, Bhattacharyya S, Dudeja PK, Tobacman JK. Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells. Am J Physiol-Gastrointes Liver Physiol 292(3):G829-38, 2007.
    

47. Reidling JC, Said HM. Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo. Amer J Physiol-Cell Physiol. 292(4):C1305-12, 2007.
    

48. Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK. Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes. Dig Dis Sci 52(10):2766-74, 2007.
    

49. Bhattacharyya S, Borthakur A, Pant N, Dudeja PK, Tobacman JK. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. Am J Physiol-Gastroint Liver Physiol 293(2):G429-37, 2007.
    

50. Vishnubhotia R, Sun S, Huq J, Bulic M, Ramesh A, Guzman G, Cho M, Glover SC. ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging. Lab Invest 87(11):1149-58, 2007.
    

51. Circu ML, Rodriguez C, Maloney R, Moyer MP, Aw TY. Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis. Free Radic Biol Med. 44(5):768-78, 2007.
    

52. Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK. Carrageenan induces cell cycle arrest in human intestinal epithelial cells in vitro. J Nutr 135(3):469-75, 2008.
    

53. Duthie SJ, Mavrommatis Y, Rucklidge G, Reid M, Duncan G, Moyer MP, Bestwick CS, Pirie IP. The response of normal human colonocytes to folate deficiency in vitro: functional and proteomic analysis. J. Proteome Res. (in press).
    

54. Zimmermann D, Hartmann M, Moyer MP, Nolte J, Baumbach J. Metabolics of human colon cell lines. Biochem J (in press).
    

55. Lefkimmiatis K, Srikanthan M, Moyer MP, Curci S, Hofer AM. Ca2+ store depletion is directly coupled to increases in cAMP via STIM1 and STIM2. Nature Biotechnology (in press)*
    

56. Na X, Kim H, Moyer MP, Pothoulakis C, Lamont JT. Gp96 is a human colonocyte plasma membrane binding protein for clostridium difficile toxin A. Infect Immun 2008 Apr 14; Epub ahead of print, PMID 18411291.
    

57. Nguyen AV, Stamos MJ, Moyer MP, Planutis K, Hope C, Holcombe RF. Resveratrol and grape powder: Effect on Wnt pathway target gene expression in colonic mucosa and colon cancer in humans – a phase I clinical trial. J Nutrition (in press)