Regenerative Medicine

Definition Broadly defined, regenerative medicine is defined as innovative medical therapies that will enable the body to repair, replace, restore and regenerate damaged or diseased cells, tissues and organs. Regenerative medicine includes cell/tissue therapies manufacturing in a personalized medicine context. It encompasses a variety of research and targeted therapies including cells, gene therapy, tissue engineering, biomaterials engineering, growth factors, and transplantation. These include surgical repair, cell-based vaccines, bionics and other areas important to both civilian and military medicine. Importantly, regenerative medicine also promises to extend healthy life spans and improve the quality of life by supporting and activating the body’s natural healing.

INCELL Core Capabilities and Hope

INCELL’s strong capabilities in Regenerative Medicine build on the company’s staff who have decades of experience, combined with exceptional CORE PLATFORM Technologies that include cell culture methods, trade secrets, and applications knowledge. With its own capabilities and by partnering with scientists worldwide, INCELL intends to bring those capabilities to Personalized Medicine with applications of normal stem cells and cancer cells to provide new therapies to patients who need them.

Exciting research activities and applications of cell therapies and stem cells will include: repair of damaged heart muscle after a heart attack, replacement of skin for burn victims, restoration of movement after spinal cord injury and regeneration of pancreatic tissue to produce insulin for people with diabetes.

Some of the areas of INCELL on-going work in regenerative medicine include:

Human Cell Biotechnology Clinical Protocols & Applications Cryopreservation; Cell Bio Banks Genomics, Proteomics, etc. Stem & Progenitor Cells Multiple Diseases & Organ Sites Gastrointestinal Cells & Diseases Transplantation/Repair Autologous; Allogeneic Neural Injury & Wound Healing

Oncology/Tumor Cells

• Culture, Characterize & Test

• Many Common & Rare Tumors

• Customized Therapy

• Vaccines & Adoptive Immunotherapy

• Personalized Treatment Options
  

Manufacturing/ Testing

• PLATFORM Formulae, Tools & Methods

• Cells, Tissues, & Their Components

• Specialty Reagents & Novel Processing

• BIO-Products, e.g., Monoclonal Abs

INCELL’s Proprietary Unique Media Formulae are CORE PLATFORM Technologies Applied to its Regenerative Medicine Capabilities

M3 Media PLATFORMS to Grow Human Stem/Progenitor Cells

• Promotes growth of normal stem cells from multiple organs

• Supports growth of tumors of epithelial, mesenchymal, and lymphoid origins

• Potential useful to grow cells for clinical uses, e.g., transplant therapy and cell-based vaccines

• Allows expansion of cells and in vitro, high quality cell-based testing

ACE™ Media PLATFORM

• Chemically defined medium

• Excellent for cell-derived products, including vaccines and monoclonal antibodies

• Supplements can be added for customization

Quality Cryopreservation Media with Multi-mechanism cell protection PLATFORM Technologies

• CPZ™ complex medium for all cells; including fragile types, e.g., neural cells

• EZ-CPZ™: Chemically defined, animal component free medium for cryopreservation with vitrification (glass-like encapsulation) of cells

UTM™ Universal Transport Medium

• Simple, double buffered defined medium useful for transport of normal or tumor tissues from collection sites to INCELL

FDA Master Files

• Above media are in FDA Drug and Device Master Files and are available for clinical use by INCELL and its customers

Product Pipeline